The action of aminoguanidine on the liver of trained diabetic rats

نویسندگان

  • Edmara Tereza Meira e Nico
  • Patrícia Rosa de Oliveira
  • Leonardo Peres de Souza
  • Franco Dani Campos Pereira
  • Maria Andréia Delbin
  • Angelina Zanesco
  • Maria Izabel Camargo-Mathias
چکیده

BACKGROUND This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques. METHODS THE RATS USED IN THIS STUDY WERE DIVIDED INTO FIVE GROUPS: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine. RESULTS The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels. CONCLUSION Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin.

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عنوان ژورنال:

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2013