The action of aminoguanidine on the liver of trained diabetic rats
نویسندگان
چکیده
BACKGROUND This study evaluated the effect of aminoguanidine on liver of diabetic rats subject to physical exercises using histological and histochemical techniques. METHODS THE RATS USED IN THIS STUDY WERE DIVIDED INTO FIVE GROUPS: sedentary control, sedentary diabetic, trained diabetic, sedentary diabetic and treated with aminoguanidine, trained diabetic and treated with aminoguanidine. RESULTS The results showed no effect of aminoguanidine on the liver tissue, although there was improvement with exercise training showing cytological, morpho-histological and histochemical alterations in liver cells of animals from groups trained diabetic and/or treated diabetic compared to those individuals in the sedentary control and sedentary diabetic. These changes included: hepatocytes hypertrophy, presence and distribution of polysaccharides in the hepatocytes cytoplasm and, especially, congestion of the liver blood vessels. CONCLUSION Our results suggest that aminoguanidine is not hepatotoxic, when used at dosage of 1 g/L for the treatment of diabetes complications, and confirmed that the practice of moderate physical exercise assuaged the damage caused by diabetes without the use of insulin.
منابع مشابه
The effects of nitric oxide production blockage by aminoguanidine on passive avoidance memory and expression of Bcl-2 family genes in diabetic rats
Introduction: Memory impairment is one of the complications of diabetes which may accompany with changes in expression of apoptotic and antiapoptotic genes. The aim of the present study was the evaluation of intra-hippocampal injection of aminoguanidine (AG), as an antioxidant and inducible nitric oxide synthase inhibitor, on passive avoidance memory and Bcl-2 family genes expression in diab...
متن کاملPreventive Effect of Garlic (Allium sativum L.) on Serum Biochemical Factors and Histopathology of Pancreas and Liver in Streptozotocin-Induced Diabetic Rats
Antidiabetic action of garlic is established in animal studies. Since all of the pervious studies have focused on the therapeutic role of garlic, this study investigated the preventive effect of garlic juice on biochemical factors and histological features in Streptozotocin (STZ)-induced diabetic rats. Forty male rats were divided into five groups (n = 8): 1-Normal group (N), 2-Normal+Garlic gr...
متن کاملAnti-diabetic effect of Capparis spinosa L. root extract in diabetic rats
Objective: Diabetes mellitus is the most common metabolic disorders with severe impact on quality of life. Reducing serum glucose levels and normalization of serum lipid is of great clinical importance for treating diabetes. To our knowledge, there are not any evidences about the anti-diabetic action of capparis spinosa root. In the present study the effects of the C. spinosa root extract on di...
متن کاملPreventive Effect of Garlic (Allium sativum L.) on Serum Biochemical Factors and Histopathology of Pancreas and Liver in Streptozotocin-Induced Diabetic Rats
Antidiabetic action of garlic is established in animal studies. Since all of the pervious studies have focused on the therapeutic role of garlic, this study investigated the preventive effect of garlic juice on biochemical factors and histological features in Streptozotocin (STZ)-induced diabetic rats. Forty male rats were divided into five groups (n = 8): 1-Normal group (N), 2-Normal+Garlic gr...
متن کاملThe Effect of 8 Weeks Endurance Training on Myocardial GLUT4 and Liver Enzymes in Type 2 Diabetic Rats
Background: Over the years type 2 diabetes, in addition to causing irreversible effects on various parts of the body, also causes liver dysfunction and increases the risk of heart failure, but due to the lack of physical symptoms, less attention has been paid. So, the aim of this study was to determine the effect of 8 weeks of endurance training on diabetic indexes and myocardial GLUT4 and live...
متن کامل